Current Vaccine Development against Plague
نویسنده
چکیده
Yersinia pestis, the causative organism of the plague, has played an important role in shaping human history. Plague is an illness that may manifest in bubonic, pneumonic, or septicemic form. Natural outbreaks devastated entire populations in medieval times and an estimated 200 million humans were killed by plague throughout history. The organism can still be found today throughout the world, including the United States. Approximately 2,000 cases of plague are reported each year to the World Health Organization. The potential use of the bacteria in modern times as an agent of bioterrorism makes understanding this organism a priority. The author reviews the current vaccine development against plague after a brief description of the history of plague pandemics.
منابع مشابه
Plague Vaccine Development: Current Research and Future Trends
Plague is one of the world's most lethal human diseases caused by Yersinia pestis, a Gram-negative bacterium. Despite overwhelming studies for many years worldwide, there is no safe and effective vaccine against this fatal disease. Inhalation of Y. pestis bacilli causes pneumonic plague, a fast growing and deadly dangerous disease. F1/LcrV-based vaccines failed to provide adequate protection in...
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